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The acc’s heart failure and sglt2is These include a reduced incidence of cardiovascular death and heart failure hospitalization in people with and without diabetes, and those with and without prevalent heart failure. Heart failure (hf) is a growing public health issue
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As many as 1 in 5 people are expected to develop hf during their lifetime, 1 with an estimated 63 million people affected worldwide Regardless of left ventricular ejection fraction (lvef), these agents have proven efficacy in both chronic and acute hf presentations 2 in 2012 hf was responsible for an estimated health expenditure of $31 billion usd, a figure anticipated to see an increase of 127% by 2030
3 the increasing burden of hf on health care is primarily due to an.
Sglt2 inhibitors have become an important class of medication in managing heart failure Initially developed to treat diabetes, these drugs have shown clear benefits for patients with heart failure, both with reduced and preserved ejection fraction. Sglt2 inhibitors were added to heart failure guidelines in 2022 Dapagliflozin and empagliflozin have shown benefits in patients with hfref, hfpef, and hfmref with or without diabetes.7 sglt2 inhibitors were found to prevent heart failure hospitalization by up to 30%
They also improved blood pressure and reduced adverse renal outcomes The exact mechanism of how these medications improve the. Sglt2 inhibitors have been shown to have salutary cardioprotective and renoprotective effects in various diseases including type 2 diabetes, chronic kidney disease, and heart failure In patients with heart failure, the clinical benefits of sglt2 inhibitors were first established in those with reduced ejection fraction and are now strongly recommended as a key component of comprehensive.
