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The tme is deeply involved in the mechanisms of drug resistance also in gbm, as discussed above for other cancers We seek to uncover novel genetic, epigenetic, and metabolic alterations contributing to drug resistance, and to map molecular pathways that cancer cells exploit to survive. Specifically, resistance to immunotherapy is one of the peculiar mechanisms shown to be involved in the acquisition of treatment resistance in gbm tumors.
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Despite decades of clinical and preclinical studies, the markers and mechanisms of resistance to cancer immunotherapy, particularly immune checkpoint blockade (icb), remain elusive The primary aim of this research topic is to enhance our understanding of resistance mechanisms in cancer therapy, thereby improving treatment outcomes In this review, we address the current clinical challenges regarding icb treatment by examining the underlying cellular and molecular contributors to resistance and newly developed agents to target them.
We summarise the current utility and limitations of two clinically established biomarkers
Improved knowledge of ici resistance mechanisms will help to identify prognostic and predictive biomarkers and help to determine the most successful combinations with the optimal order of administering these treatment regimens. Mechanisms of cancer resistance to immunotherapy intrinsic mechanisms of tumor immune resistance include changes in antitumor immune response pathways, alteration of signaling pathways in tumor cells, and other changes in tumor cells that lead to an inhibitory immunosuppressive microenvironment. A significant drug resistance mechanism is the reactivation of bypass pathways, which cancer cells use to evade therapeutic blockades Combination therapies targeting parallel or sequential pathways can overcome this challenge.
Available data on the full spectrum of resistance mechanisms remain limited, partly due adcs structural and mechanistic complexity, which enables a wide range of potential resistance pathways.
